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    Explore 52 peer-reviewed articles across the MTU journal network.

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    2 of 2 articles

    MTUApr 8, 2024

    Chemical constituents and antioxidant activities of the essential oil from stem of Olax manii

    Odusina, B. O., Oyeyemi et al. (13 contributing authors)

    Olax manii  stems were collected in Ikire, Osun State, Nigeria. Using the hydrodistillation process, essential oil was extracted from the stem of  Olax manii.  To ascertain the chemical composition of the essential oil, Gas chromatography mass spectrometry (GCMS) technique analysis was employed. Using doses ranging from 100 to 25 µg/ml, the antioxidant properties of the essential oil were examined using the 2, 2-Diphenyl-1 picryl hydroxyl (DPPH) radical scavenging activity method. The results of the Gas chromatography mass spectrometry (GC-MS) analysis indicated that the main chemical constituents were squalene (6.18 %), amyrone (4.49%), and neophytadiene (4.22 %). The minor constituents were identified as limonene (0.23 %), caryophyllene (0.31 %) and phytol (1.62 %). The essential oil radical scavenging activity at a concentration of 100 mg/ml was compared to the standard ascorbic acid at the same concentration and it revealed that the essential oil exhibited a significant percentage radical scavenging activity of 78.52 %. The percentage radical scavenging activities increased with increase in concentrations of the essential oil. The Essential oil constituents which possess antioxidant activities could be responsible for the antioxidant activities and ethnomedicinal uses of  Olax manii.
    Essential oilAntioxidant Constituents&nbspDPPH&nbsp
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    MTUOct 4, 2023

    Hypolipidemic effect of aqueous and ethanol extracts of Alafia barteri (leaf and root) in formaldehyde-induced arthritis in male mice

    Kolawole, I. O., Ebuehi et al. (10 contributing authors)

    Alafia barteri  is valued for its effectiveness in the traditional medicine system in Nigeria and other African countries. This study aims at evaluating the hypolipidemic effect of the aqueous and ethanol leaf and root extracts of  Alafia barteri  in formaldehyde-induced arthritic mice. 77 healthy Swiss albino male mice (30-35 g) were randomized into eleven groups of five mice each and extracts were administered for 10 days at 200 mg/kg and 400 mg/kg. Arthritis was induced by sub-plantar injection of 0.1 mL of 2 % formaldehyde. Serum lipid profile was evaluated after blood sample collection. Results of this study revealed that the aqueous and ethanol leaf extracts   caused significant reduction(p˂0.05) in triglyceride and total cholesterol levels, but increased HDL-cholesterol levels compared to the arthritic control which is suggestive of their hypo-lipidemic effects in arthritic mice. 
    Alafia barteriArthriticSub-plantarHypolipidemic
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